منابع مشابه
Bence Jones proteinuria in multiple sclerosis.
We report our findings of Bence Jones proteins (monoclonal free light chains of immunoglobulins) in concentrated urines of patients with multiple sclerosis, by using agarose electrophoresis and immunofixation. The lack of such findings in urines from healthy subjects and patients with other neurological disorders should stimulate further investigation.
متن کاملBence Jones proteinuria and myeloma kidney.
Bence-Jones proteinuria refers to urinary excretion of monoclonal light chains. It results from exclusive production of one light chain, or the unbalanced synthesis of heavy and light chains, with the latter being in excess. Free Kor A-light chains are therefore excreted alone or in addition to complete immunoglobulin molecules carrying the same light chain type. Free light chains are low molec...
متن کاملThe outcome of idiopathic Bence Jones proteinuria.
The authors studied two patients with idiopathic Bence Jones proteinuria (BJP) that fulfill all the criteria proposed by Kyle and Greipp. None had evidence of overt multiple myeloma, of its variants, of primary systemic amyloidosis, or of other lymphoid tumors. In a patient with kappa type idiopathic BJP an elevation of a labelling index was found when an evolving myeloma developed 2 years late...
متن کاملStudies of Bence Jones Proteins by Immunonephelometry*t
Plasma cell dyscrasia is a disease caused by a monoclonal population of plasma cells. Most often the workup for this disease is prom pted by the appearance of a paraprotein in serum, but a significant num ber of cases exhibit only a Bence Jones protein. Immunofixation electrophoresis is the most sensitive m ethod presently used for identifying Bence Jones protein uria. This methodology is labo...
متن کاملMetabolism of Bence Jones Proteins.
Bence Jones proteins are molecules of about 40,000 mol wt present in the urine of many patients with plasma cell malignancy. These microglobulins, which are synthesized in plasma-cell tumors (1, 2), share many immunochemical and physicochemical features with the larger 6.6 S y-globulins. That Bence Jones proteins are similar to or identical with components of the larger y-globulins has been sug...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1917
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)86769-2